Regular users build up a physical tolerance, requiring larger doses for the same effect. Oral dosage forms of methaqualone hydrochloride were manufactured as capsules, whereas oral dosage forms of methaqualone free-base were manufactured as tablets. While the salt methaqualone hydrochloride is typically used clinically, methaqualone free-base was also marketed, namely as the methaqualone component of Mandrax, a combination drug which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet. Methaqualone peaks in the bloodstream within several hours, with a half-life of 20–60 hours. A dose of 8000 mg is lethal and a dose as little as 2000 mg could induce a coma if taken with an alcoholic beverage. The standard single tablet adult dose of Quaalude brand of methaqualone was 300 mg when made by Lemmon. It resembles barbiturate poisoning, but with increased motor difficulties and a lower incidence of cardiac or respiratory depression. Īdditional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest. Overdose Īn overdose can lead to nervous system shutdown, coma and death. Methaqualone was not recommended for use while pregnant and is in pregnancy category D. These properties explain why methaqualone was originally mainly prescribed for insomnia. When GABA activity is increased, blood pressure drops and breathing and pulse rates slow, leading to a state of deep relaxation. Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates. This use means the drug is controlled in most countries, and is so under Schedule II of the United Nations Convention on Psychotropic Substances. The substance was sold both as a free base and as a salt (hydrochloride). Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s, known variously as "ludes" or "disco biscuits" due to its widespread use during the popularity of disco in the 1970s, or "sopers" (also "soaps") in the United States and Canada, and "mandrakes" and "mandies" in the United Kingdom, Australia and New Zealand. Its use peaked in the early 1970s for the treatment of insomnia, and as a sedative and muscle relaxant. In 1962, methaqualone was patented in the United States by Wallace and Tiernan. The sedative–hypnotic activity of methaqualone was first noted in 1955. It is a member of the quinazolinone class. Commercial production of methaqualone was halted in the mid-1980s due to widespread abuse and addictiveness. It was sold under the brand names Quaalude ( / ˈ k w eɪ l uː d/ KWAY-lood) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet, mostly in Europe. No Nudity! If it's NSFW mark it properly or it will be removed.Methaqualone is a hypnotic sedative. Put those in the body of post or make a comment under your post. Product names or model numbers in posts titles will be removed. No Political posts that are not directly related to Legalization Efforts.Ĩ - No Product Names / Models in title of posts. Please use white light or flash.Ĭontinuing to post with blurple light will lead to your post being removed.Ībsolutely NO giveaways or links to them unless pre-approved first. We will remove your posts if you claim to be underage or ask when you should start smoking.īlurple light makes it almost impossible to help diagnose plant problems. The legal age for smoking is typically 18 and it is recommended that you do not start smoking weed until your brain has fully developed at age 25. The solicitation is against Reddit's terms of service and falls under prohibited transactions for illegal goods found here Racist, sexist, or LGBTQIA+ slurs are not permitted.ģ - Attempting to buy, sell, trade is prohibited.Īny attempts to buy, sell, trade or source/offer (including testers) will result in a permanent ban, even on the first occasion. Make your point without resorting to personal attacks, name-calling. Learn more about self-promotion on Reddit Here No Affiliate Links! No Referrals! Direct links only. This includes, but is not limited to, posts promoting specific products or name brands, promoting YouTube channels or other forms of Social Media (including watermarks), and linking to online stores or other places designed to make money. All forms of advertising and self-promotion are strictly prohibited.
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